In The FDA says that people who have liver disease or liver problems should talk to their doctors before taking kava. Talk to your doctor if you take other medicines that affect the liver.
People who are pregnant or breastfeeding shouldn't use kava. People with depression or bipolar disorder shouldn't use kava. It may make your depression worse.
If you use machinery or do other activities that need you to be alert, don't use kava. It may make you drowsy. It may keep you from being able to drive a car safely.
Kava may increase the effects of central nervous system medicines. These include depressants, such as alcohol, barbiturates, and benzodiazepines.
Taking alprazolam and kava together has caused comas.