Sepsis is a serious illness caused by the body's extreme immune response to an infection. Bacteria are the most common cause of an infection that leads to sepsis. The most common infections are pneumonia, abdominal infections, and urinary tract infections. Sepsis can lead to organ failure. When this happens, it needs to be treated in the intensive care unit (ICU) at a hospital. In the worst case, sepsis can be life-threatening. If a person survives sepsis, there can be long-term effects, both physical and psychological, such as fatigue, decreased mental functioning, sleep problems, chronic pain, and even posttraumatic stress disorder (PTSD). This is called post sepsis syndrome (PSS).