Lymph nodes are small clumps of tissue that are part of the body's immune system. If melanoma spreads, it often goes to nearby lymph nodes first.
The sentinel nodes are the first lymph nodes that tumor cells spread into. These are the first places that cancer is likely to spread. Depending on the thickness of your tumor, the sentinel nodes may need to be removed and checked for cancer cells. A sentinel node biopsy is a test that's often done during surgery to remove melanoma. This test helps the surgeon know which lymph nodes to remove. If you're going to have a sentinel node biopsy, your surgeon can tell you more about what to expect. Locating the sentinel lymph nodes (sentinel lymph node mapping) is best done before the wide local excision.
Sometimes lymph nodes can look swollen (enlarged) on an imaging test such as a CT scan or they can be felt during an exam. If you have these signs, a needle biopsy might be done to see if the lymph nodes contain melanoma cells. If they do, all of the lymph nodes in the area might be removed. This is called a lymph node dissection.